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JOINT DEGENERATION: MOUSE MODELS

Published on AidPage by IDILOGIC on Jun 24, 2005
Administered by:

Department of Health and Human Services, National Institutes of Health, National Institutes of Health
(see all US Federal Agencies)

Explore all postings for this grant program:
  • Original Grant - Aug 16, 2004
Applications Due:


Multiple Receipt Dates - See Link to Full Announcement for details.

total funding: Not Available
max award: $200,000
min award: none
cost sharing, matching: No
number of awards: Not Available
type of funding: Grant
Description:

This announcement solicits proposals of research employing genetically
defined and genetically modified mouse models to explore the biological
mechanisms underlying non-inflammatory joint degeneration, or osteoarthritis.
Inflammatory processes are evident in late stages of osteoarthritis, and are
likely to be major contributors to the chronic pain that is the most common
symptom of the condition. However, for the purpose of this initiative,
osteoarthritis is distinguished from diseases, such as rheumatoid arthritis,
in which inflammation arising from autoimmunity is the primary cause of
tissue damage. In contrast, the root causes of joint degeneration in
osteoarthritis remain unclear. Increasing knowledge of molecular mechanisms
in cartilage and bone biology, along with advances in the genetic
manipulation of mice, have yielded new concepts and new animal models that
may be relevant to osteoarthritis in humans. This Program Announcement is
intended to accelerate the characterization of new models and the testing of
hypotheses that could lead to improved diagnosis and treatment of
osteoarthritis.

Who can apply:

Anyone/General Public
City Or Township Governments
County Governments
Federally Recognized Indian Tribal Governments
Independent School Districts
Individual/Family
Minority Group
Native American Organization
Non-Government - General
Nonprofits Having A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Nonprofits That Do Not Have A 501(C)(3) Status With The IRS, Other Than Institutions Of Higher Education
Other Private Institution/Organization
Private Institutions Of Higher Education
Private Nonprofit Institution/Organization (Includes Institutions Of Higher Education, Hospitals)
Profit Organization
Public And State Controlled Institutions Of Higher Education
Public Housing Authorities/Indian Housing Authorities
Quasi-Public Nonprofit Institution/Organization
Small Business (Less Than 500 Employees
Special District Governments
State (Includes District Of Columbia; Includes Institutions Of Higher Education And Hospitals)
U.S. Territories And Possessions (Includes Institutions Of Higher Education, Hospitals)

Eligible functional categories:
Funding Sources:

Aging Research
Arthritis, Musculoskeletal and Skin Diseases Research
Oral Diseases and Disorders Research

More Information:

http://grants.nih.gov/grants/guide/pa-files/PA-04-139.html

If you have problems accessing the full announcement, please contact: NIH OER Webmaster

Address Info:

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